August 2019 Trials of the Month

Type

Acronym

Study Title

Description

Site(s)

Breast

CAPITELLO-290

A Phase III Double-blind Randomised Study Assessing the Efficacy and Safety of Capivasertib + Paclitaxel Versus Placebo + Paclitaxel as First-line Treatment for Patients with Histologically Confirmed, Locally Advanced (Inoperable) or Metastatic Triple-Negative Breast Cancer (TNBC)

  • Triple-Negative Breast Cancer
  • Systemic Therapy

North York General Hospital

GU

GALAHAD

A Phase II Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resistant Prostate Cancer and DNA-Repair Anomalies

  • Metastatic Castration-Resistant Prostate Cancer
  • Systemic Therapy

Sunnybrook Health Sciences Centre

GI

EMERALD-1

A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Transarterial Chemoembolization (TACE) in Combination With Either Durvalumab Monotherapy or Durvalumab Plus Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma

  • Hepatocellular Carcinoma
  • Systemic Therapy

Sunnybrook Health Sciences Centre

HEME

MCRN-009

A Phase II Open Label Study of an Accelerated Infusion Rate of Daratumumab in Patients With Relapsed and Refractory Multiple Myeloma

  • Relapsed and Refractory Multiple Myeloma
  • Systemic Therapy

Kingston General Hospital

LUNG

KEYNOTE-495

A Phase II Precision Oncology Study of Biomarker-Directed, Pembrolizumab-(MK-3475, SCH 900475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer

  • Non-Small Cell Lung Cancer
  • Systemic Therapy

Sunnybrook Health Sciences Centre

Gyne

 

OVC.2

 

A Randomized Phase II/III Study of the Combination of Cediranib and Olaparib Compared to Cediranib or Olaparib Alone, or Standard of Care Chemotherapy in Women With Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (COCOS)

  • Ovarian, Fallopian Tube, or Peritoneal Cancer
  • Systemic Therapy

 

Royal Victoria Regional Health Centre

Any

SPARE-HF

Randomized Double Blind Placebo Controlled Trial of Statins for the Primary Prevention of Heart Failure in Patients With Cancer Receiving Anthracycline Based Chemotherapy

  • Patients receiving anthracycline-based chemotherapy

Toronto General Hospital, St. Michael’s Hospital, Sunnybrook Health Sciences Centre